New research found a link between GLP-1 use in people with diabetes and an elevated chance of wet AMD, which can cause blindness. AACE President Scott D. Isaacs, MD, FACP, FACE, explains that while the study identifies an association, it doesn’t prove that the medications cause the condition, as other unmeasured factors such as smoking, UV exposure, and dietary habits may have influenced the outcome. For most patients, the cardiometabolic benefits outweigh the low risk of wet nAMD; however, in older adults with preexisting retinal conditions and prolonged GLP-1 use, risk-benefit discussions are important.