Triglycerides, Atherosclerosis, and Cardiovascular Outcome Studies: Focus On Omega-3 Fatty Acids

Yehuda Handelsman and Michael D. Shapiro

Endocrine Practice - Jan 2017, Vol. 23, No. 1 (January 2017) pp. 100-112

The atherogenic potential of triglyceride-rich lipo-proteins was postulated nearly 70 years ago by Moreton; Zilversmit later corroborated the concept in a comprehen-sive review of postprandial lipid effects in atherogenesis (1,2). Mechanisms by which triglyceride-rich lipopro-teins may contribute to atherosclerosis have been recently reviewed and are shown in Figure 1 (3,4). Epidemiologic studies worldwide in multiple cohorts have consistent-ly demonstrated the direct relationship between serum triglyceride levels and risk of coronary heart disease (CHD), which in many cases was found to be independent of other cardiovascular (CV) risk factors (5-13).