Lipid/Cardiovascular Disorders/Hypertension

Endocrine Practice - May 2016, Vol. 22, No. Supplement 2 (May 2016) pp. 115-126

Growth hormone (GH) has an irreplaceable metabolic role in the body, especially in adipose tissue, bone and muscle, which are major targets of GH action (1,2). GH deficiency (GHD) in adults is a well-defined clinical condition characterized by abnormal body composition, impaired physical activities, depressed mood, and decreased quality of life (3). Indeed, untreated adult GHD (AGHD) is associated with cardiometabolic risk factors such as glucose intolerance, insulin resistance (IR), dyslipidemia, and altered cardiac structure and function, but GH replacement therapy (GHRT) can combat these outcomes (4–7).