Asymmetric Dimethylarginine Levels and Atherosclerosis Markers in Cushing Syndrome

Cemile Gulbas Ozsurekci, Mujde Akturk, Cigdem Ozkan, Ozlem Gulbahar, Alev Eroglu Altinova, Muhittin Yalcin,
Emre Arslan and Fusun Toruner

Endocrine Practice - Sep 2016, Vol. 22, No. 9 (September 2016) pp. 1088-1095

Diabetes mellitus (DM), dyslipidemia, hypertension (HT), and obesity are common comorbidities of Cushing syndrome (CS) as a consequence of hypercortisolism. It is well-known that these conditions are related to atheroscle-rosis (1). Increased rates of cardiovascular disease (CVD) are the primary cause of mortality and morbidity in CS (1,2). It has been shown that high cortisol levels lead to accelerated atherosclerosis and CVD, but the mechanisms behind this effect remain unclear (2).