Associations Between Triglyceride/High-Density Lipoprotein Cholesterol Ratio and Micro- and Macroangiopathies in Type 2 Diabetes Mellitus

Mei-Yueh Lee, Pi-Jung Hsiao, Jiun-Chi Huang, Wei-Hao Hsu, Szu-Chia Chen, Jer-Ming Chang and Shyi-Jang Shin

Endocrine Practice - Jul 2018, Vol. 24, No. 7 (July 2018) pp. 615-621


The prevalence of type 2 diabetes mellitus (DM) is increasing worldwide. The morbidity and mortality associated with DM are mainly caused by micro- and macrovascular complications and include diabetic retinopathy (DR), diabetic nephropathy, diabetic neuropathy, coronary artery disease (CAD), cerebrovascular disease (CVA), and peripheral artery occlusive disease (PAOD). Furthermore, vascular complications are the leading cause of end-stage renal disease, acquired blindness, various neuropathies, and advanced atherosclerosis in patients with diabetes (1). Known risk factors for micro- and macrovascular complications include poor glycemic control, duration of DM, hypertension, insulin resistance and dyslipidemia (2–5). Aggressive control of both blood glucose and blood pressure can potentially be beneficial in the prevention of micro- and macroangiopathies in patients with DM, however this is often difficult due to the associated risks of hypoglycemia and hypotension (6,7). Therefore, identifying other targets and treatments to slow the development of micro- and macroangiopathies in patients with type 2 DM is an important issue.