Off-label use and misuse of testosterone, GH, thyroid hormone, and adrenal supplements have become increasingly prevalent. Many patients seek treatment for common nonspecific symptoms such as fatigue, low energy, poor sleep, weight gain, and lower libido. Unfortunately, some clinics and websites lead people to believe that their symptoms are attributable to a deficiency of a hormone and that treatment with this hormone will eliminate their symptoms. While it is true that aging and chronic diseases are associated with a decline in serum concentrations of testosterone and GH, there is no scientific evidence to support prescribing these hormones for anti-aging purposes. Physicians and other health-care professionals should therefore only prescribe testosterone, GH, thyroid hormone, and glucocorticoids to patients with clearly established diagnoses of male hypogonadism, GH deficiency, hypothyroidism, adrenal insufficiency, and other conditions where these medications are an accepted standard treatment.