Registration

FRIDAY, AUGUST 15, 2008
5:00-8:00 p.m. Buffet Dinner
"Integrated Neurohormonal Approach to Diabetes and Obesity:
Therapeutic Potential of Peptides - and Leptin Agonism."
Paul Marshall, Vice President of Operations, Amylin Pharmaceuticals
Sponsored by Amylin Pharmaceuticals

SATURDAY, AUGUST 16, 2008

7:00-7:30 a.m. Breakfast – Exhibit Hall Open

7:30-7:45 a.m. Welcome
Mario Skugor, MD, Program Chair
Ohio River Region AACE President
Morning Moderator – Mario Skugor, MD

7:45-8:30 a.m. Neuroendocrine Regulation of Non-Exercise Activity
Thermogenesis (NEAT) – Role in Obesity - Colleen Novak, PhD
Objectives

• Understand the concept of non-exercise activity thermogenesis (NEAT)
• Understand potential role of NEAT in development of obesity
• Understand the neural and endocrine mechanisms systems of NEAT, the individual differences in NEAT, and the effects of diet on NEAT

8:30-9:15 a.m. Advances in DM Stem Cells
Lawrence Chan, MD, PhD
Objectives

• An explanation of the pathophysiology of diabetes so the audience would understand the background for current and future research on treatment
• Latest research on the treatment of type 1 diabetes and how it works in animal experiments
• Recent research on our experimental therapy for reversal of obesity as tested in animals and prospects for its future applications

Program Agenda
9:15-10:00 a.m. Toward the Cure of Diabetes
Aaron Vinik, MD, PhD, FCP, FACP

• Provide an overview of the limitations of pancreatic or islet transplantation
• Discuss the potential for induction of islet neogenesis from protodifferentiated stem cells resident in the pancreas
• Consider the role of INGAP and other factors in the induction and prevention of apoptosis of beta cells in the quest for a cure for diabetes
• Participants will be enlightened on the animal data generated from transgenic models as well as the results of early phase 2 studies in humans.

10:00-10:15 a.m. Break – Exhibit Hall Open

10:15-11:00 a.m. Thyroid Nodule Management – Panel Discusion
Mira Milas, MD
Sethu Reddy, MD, MBA, FRCPC, FACP, MACE
Objectives

• We will review principles of management of thyroid nodules
• We will review role of ultrasound, RAI uptake and scan, and FNA in management of thyroid nodules
• We will review indications for surgical removal of thyroid nodules

11:00-11:45 a.m. Role of TSH-R mRNA (RT-PCR) in Thyroid Tumors Management
Manjula Gupta, PhD

• Describe the limitations of current management modalities for thyroid cancer i.e. fine needle aspiration (FNA) biopsy for preoperative diagnosis and serum thyroglobulin for monitoring recurrent disease postoperatively
• Describe the role of molecular markers especially TSHR mRNA in the detection of thyroid cancer preoperatively and its synergy with FNA and ultrasound findings
• Describe the role of TSHR mRNA in the detection of residual/metastatic disease

11:45-12:45 p.m. Lunch / ORR – AACE Business Meeting

12:45-1:00 p.m. Break – Exhibit Hall Open
Afternoon Moderator – Elena Christofides, MD, FACE

1:00-1:45 p.m. Fellows Case Presentations – Pheochromocytoma/Diagnostic Evaluation of Cushing Disease
Daud Sameera, MD
Harpreet Bajaj, MD, MPH

• Describe clinical features of pheochromocytoma
• Review laboratory evaluation and imaging characteristics of a pheochromocytoma
• Review the available treatment options
• We will present a case of a patient with Cushing disease
• We will review the pathophysiology of Cushing disease
• We will discuss the diagnostic evaluation Cushing disease, and will also discuss the management of Cushing disease

1:45-2:30 p.m. A Surgeon's View: Ultrasonography for Preoperative and Postoperative Management of Thyroid and Parathyroid Disease
Mira Milas, MD
Objectives

• Review the role of ultrasound in the preoperative and postoperative evaluation of patients with thyroid cancer
• Recognize abnormal cervical lymphadenopathy
• Develop familiarity with ultrasound appearance of the postoperative neck
• Identify pearls and pitfalls in the identification of enlarged parathyroid glands

2:30-3:15 p.m. Non-Invasive Parathyroidectomy – Case Against It
Erin Berber, MD

• Understand theoretical advantages of minimallyinvasive parathyroidectomy
• Understand the principles of minimally-invasive parathyroidectomy
• Review of the results of minimally invasive parathyroidectomy in Cleveland Clinic

3:15-3:30 p.m. Break – Exhibit Hall Open

3:30-4:15 p.m. Male Hypogonadism
Richard Sherins, MD

• Review the physiologic regulation of testicular function
• Elucidate the etiologies and clinical characteristics of male hypogonadism
• Recognize and manage androgen deficiency in the aging male

4:15-5:00 p.m. Adrenal Insufficiency in Critical Illness-Controversies in Diagnosis and Management
Thottahil Gopan, MD

• Review the concept of "relative adrenal insufficiency" in critically ill patients
• Identify the various tests used in the diagnose
• Review the approach to treatment of adrenal insufficiency in critically ill patients

5:00 p.m. Adjournment

5:30-7:30 p.m. Wine and Cheese Reception – Exhibit Hall Open

7:00 p.m. Shuttle Departure for Riverboat

SUNDAY, AUGUST 17, 2008

7:00-8:00 a.m. Fitness Walk

8:00-8:45 a.m. Breakfast – Exhibit Hall Open

Morning Moderator – Myron Shank, MD, PhD

8:45-9:30 a.m. Coding 2008: What a Difference a Year Makes!
S. Sethu Reddy, MD, MBA, FRCPC, FACP, MACE

• Update physicians of changes in ICD-9 codes
• Accurate coding for obesity and related disorders
• Incorporate national recommendations of optimal disease management

9:30-10:15 a.m. Introduction to Bio Identical Hormones—Evidence Based Approach
Ashok Kadambi, MD, FACE

• Distinguish between natural bio-identical hormones and their derivatives
• Correctly interpret results of the WHI study
• Review the literature supporting the use of bioidentical hormones

10:15-11:00 a.m. Management of Osteoporosis
Angelo Licata, MD, PhD, FACP, FACE

• We will review necessary diagnostic tests in patients with low bone mineral mass
• We will review the role of markers of bone metabolism I management of osteoporosis.
• We will review available treatment options for osteoporosis

11:00-11:45 a.m. Performance-enhancing Substances: Incidence of Use and Health Implications
Michael Bahrke, PhD

• Understand why and how people use anabolic steroids and related performance-enhancing substances
• Know the prevalence of anabolic steroid and related performance-enhancing substances use among adolescent school-age students, college athletes, Olympic athletes, and weight lifters
• Be aware of the physical, physiological, and psychological effects of anabolic steroids and related performance-enhancing substances
• Recognize the legislative, education, and drug testing initiatives aimed at prevention of anabolic steroid and related performance-enhancing substance use